Sustinex - Very Effective Treatment for Premature Ejaculation
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Sustinex - Very Effective Treatment for Premature Ejaculation

This is a product review of Sustinex, which is very effective in treatment of Premature Ejaculation

What is Premature Ejaculation

Premature Ejaculation (PE) is amongst the most common male sexual disorders of clinical practice. In general community, PE is estimated to happen in 4 to 39% of the men. World Health Organization has defined PE as the “recurrent or persistent ejaculation with the minimal stimulation before or shortly after the penetration as well as before the person wants it, over which the victim has little or may be no voluntary control that causes the victim or his partner hassle or distress". 

As per the International Society for the Sexual Medicine, the PE is the male sexual dysfunction, defined by the ejaculation that is always or just about always happened prior to or inside 1 minute of the vaginal penetration; as well as an inability to hold off the ejaculation on all vaginal penetrations; as well as negative personal outcomes, like distress, frustration, bother, or avoidance of sexual affair.

Dapoxetine

Dapoxetine is a first compound, which is particularly made for the treatment of PE. Dapoxetine is structurally similar to the fluoxetine, which is a prevailing SSRI. Oral dapoxetine is approved in several European countries, including Sweden, Germany, and Finland, under decentralized procedure as well as in various other countries worldwide to treat men aged between 18 to 64 years, suffering from premature ejaculation.

Dosage Administration of Sustinex

Oral dapoxetine is pointed for treatment of the men aged between 18 to 64 years, having premature ejaculation. The recommended opening dosage is 30 mg (should be taken with water) as required 1 to 3 hours before sexual intercourse (the maximum dose frequency is once in every 24 hours); the dose can be augmented to 60 mg (maximum recommended dose) as per the tolerability and efficacy. Dapoxetine can be used with/without food.

Dapoxetine is not advised for men, having moderate-to-severe hepatic impairment as well as for those getting concomitant therapy, using potent CYP3A4 inhibitors (like ritonavir, ketoconazole, telithromycin), serotonin reuptake inhibitors (like SSRIs, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors), MAOIs (Mono Amine Oxidase Inhibitors), or other medicinal or herbal products, having serotonergic effects.

Treatment of dapoxetine is not suggested for men, having severe renal impairment. Precaution is advised for administration of the dapoxetine for men, having mild or moderate renal impairment as well as in men, getting accompaniment therapy with the moderate CYP3A4 inhibitors or potent CYP2D6 inhibitors. Accompaniment dapoxetine therapy with alcohol or the recreational drugs must be avoided also.

Contraindications

1. Concomitant treatment using MAOIs, or inside 14 days of stopping treatment with the MAOI Likewise, an MAOI must not be given inside 7 days after the dapoxetine has been stopped.

2. Concomitant treatment, using SSRIs, serotonin reuptake inhibitors, TCAs (Tri Cyclic Antidepressants), SNRIs (Serotonin Norepinephrine Reuptake Inhibitors), or other medicinal or herbal products having serotonergic effects [like triptans, tramadol, L-tryptophan, lithium, linezolid) or inside 14 days of stopping treatment with all these medicinal or herbal products. Likewise, all these medicinal or herbal products must not be administrated inside 7 days after the discontinuation of dapoxetine.

3. Concomitant treatment, using thioridazine, or inside 14 days of stopping the treatment of thioridazine Likewise, thioridazine must not be given inside 7 days after the dapoxetine has been stopped.

4. Concomitant treatment of powerful CYP3A4 inhibitors like itraconazole, ritonavir, ketoconazole, saquinavir, nefazadone, nelfinavir, telithromycin, atazanavir, etc

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Comments (1)

I am 53yrs male with PE started off late for 1yr without any renal or hepatic impairment not under

contra indicated drugs. when should I use 1hr or 2hr or 3hrs before the act? Even before an oral act

also?

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